1xiw

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[[Image:1xiw.png|left|200px]]
 
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{{STRUCTURE_1xiw| PDB=1xiw | SCENE= }}
{{STRUCTURE_1xiw| PDB=1xiw | SCENE= }}
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===Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment===
===Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment===
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{{ABSTRACT_PUBMED_15534202}}
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{{ABSTRACT_PUBMED_15534202}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CD3D_HUMAN CD3D_HUMAN]] Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:[http://omim.org/entry/608971 608971]]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.<ref>PMID:14602880</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/CD3E_HUMAN CD3E_HUMAN]] The CD3 complex mediates signal transduction. [[http://www.uniprot.org/uniprot/CD3D_HUMAN CD3D_HUMAN]] The CD3 complex mediates signal transduction.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015534202</ref><references group="xtra"/>
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<ref group="xtra">PMID:015534202</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]

Revision as of 22:37, 24 March 2013

Template:STRUCTURE 1xiw

Contents

Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment

Template:ABSTRACT PUBMED 15534202

Disease

[CD3D_HUMAN] Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.[1]

Function

[CD3E_HUMAN] The CD3 complex mediates signal transduction. [CD3D_HUMAN] The CD3 complex mediates signal transduction.

About this Structure

1xiw is a 8 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Arnett KL, Harrison SC, Wiley DC. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16268-73. Epub 2004 Nov 8. PMID:15534202
  1. ↑ Dadi HK, Simon AJ, Roifman CM. Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. N Engl J Med. 2003 Nov 6;349(19):1821-8. PMID:14602880 doi:10.1056/NEJMoa031178

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OCA

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