2eb7

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[[Image:2eb7.png|left|200px]]
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==Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7==
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<StructureSection load='2eb7' size='340' side='right' caption='[[2eb7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111955 Sulfolobus tokodaii])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2eb7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The emergence of bacterial resistance to multiple drugs poses a serious and growing health concern. Understanding and deciphering the mechanisms of these multiple drug resistance regulatory proteins through structural or biochemical means is an important endeavor. Here, we present the crystal structure of ST1710 from Sulfolobus tokodaii strain 7 in two different crystal forms, at 1.80 and 2.0A, respectively. The overall structure of the ST1710 dimer shares the topology of the MarR family of proteins, with each subunit containing a winged helix-turn-helix DNA-binding motif. We also show the protein-DNA interactions by biochemical methods. Our molecular modeling analysis suggested that Asp88 and Arg90 are the key residues in ST1710 involved in the protein-DNA interactions.
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{{STRUCTURE_2eb7| PDB=2eb7 | SCENE= }}
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Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7.,Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S J Struct Biol. 2008 Jan;161(1):9-17. Epub 2007 Sep 8. PMID:17933554<ref>PMID:17933554</ref>
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===Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17933554}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017933554</ref><references group="xtra"/>
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[[Category: Sulfolobus tokodaii]]
[[Category: Sulfolobus tokodaii]]
[[Category: Kumarevel, T S.]]
[[Category: Kumarevel, T S.]]

Revision as of 00:09, 30 September 2014

Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7

2eb7, resolution 1.80Å

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