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2ahm

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[[Image:2ahm.png|left|200px]]
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==Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer==
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<StructureSection load='2ahm' size='340' side='right' caption='[[2ahm]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ahm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AHM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ahm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ahm RCSB], [http://www.ebi.ac.uk/pdbsum/2ahm PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/2ahm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Coronavirus replication and transcription machinery involves multiple virus-encoded nonstructural proteins (nsp). We report the crystal structure of the hexadecameric nsp7-nsp8 supercomplex from the severe acute respiratory syndrome coronavirus at 2.4-angstroms resolution. nsp8 has a novel 'golf-club' fold with two conformations. The supercomplex is a unique hollow, cylinder-like structure assembled from eight copies of nsp8 and held tightly together by eight copies of nsp7. With an internal diameter of approximately 30 angstroms, the central channel has dimensions and positive electrostatic properties favorable for nucleic acid binding, implying that its role is to confer processivity on RNA-dependent RNA polymerase.
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{{STRUCTURE_2ahm| PDB=2ahm | SCENE= }}
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Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer.,Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, Rao Z Nat Struct Mol Biol. 2005 Nov;12(11):980-6. PMID:16228002<ref>PMID:16228002</ref>
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===Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16228002}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2ahm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHM OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016228002</ref><references group="xtra"/>
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[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Bartlam, M.]]
[[Category: Bartlam, M.]]

Revision as of 01:10, 30 September 2014

Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer

2ahm, resolution 2.40Å

Drag the structure with the mouse to rotate

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