2bi6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2bi6" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2bi6.png|left|200px]]
+
==NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM==
 +
<StructureSection load='2bi6' size='340' side='right' caption='[[2bi6]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2bi6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ananas_comosus Ananas comosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI6 FirstGlance]. <br>
 +
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bi6|1bi6]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bi6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi6 PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Bromelain inhibitor VI from pineapple stem (BI-VI) is a unique double-chain inhibitor with an 11-residue light chain and a 41-residue heavy chain by disulfide bonds and inhibits the cysteine proteinase bromelain competitively. The structure of BI-VI in aqueous solution was determined using nuclear magnetic resonance spectroscopy and simulated annealing-based calculations. Its three-dimensional structure was shown to be composed of two distinct domains, each of which is formed by a three-stranded antiparallel beta-sheet. Unexpectedly, BI-VI was found to share a similar folding and disulfide bond connectivities not with cystatin superfamily inhibitors which inhibit the same cysteine proteinases but with the Bowman-Birk trypsin/chymotrypsin inhibitor from soybean (BBI-I). BBI-I is a 71-residue inhibitor which has two independent inhibitory sites toward the serine proteinases trypsin and chymotrypsin. These structural similarities with BBI-I suggest that they have evolved from a common ancestor and differentiated in function during a course of molecular evolution.
-
{{STRUCTURE_2bi6| PDB=2bi6 | SCENE= }}
+
Solution structure of bromelain inhibitor IV from pineapple stem: structural similarity with Bowman-Birk trypsin/chymotrypsin inhibitor from soybean.,Hatano K, Kojima M, Tanokura M, Takahashi K Biochemistry. 1996 Apr 30;35(17):5379-84. PMID:8611527<ref>PMID:8611527</ref>
-
===NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_8611527}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2bi6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ananas_comosus Ananas comosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI6 OCA].
+
</StructureSection>
[[Category: Ananas comosus]]
[[Category: Ananas comosus]]
[[Category: Hatano, K I.]]
[[Category: Hatano, K I.]]
[[Category: Cysteine protease inhibitor]]
[[Category: Cysteine protease inhibitor]]

Revision as of 08:31, 8 October 2014

NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bi6"
Personal tools