2bv6

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[[Image:2bv6.png|left|200px]]
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==CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS==
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<StructureSection load='2bv6' size='340' side='right' caption='[[2bv6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bv6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BV6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bv6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bv6 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/2bv6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Staphylococcus aureus is a human pathogen responsible for most wound and hospital-acquired infections. The protein MgrA is both an important virulence determinant during infection and a regulator of antibiotic resistance in S. aureus. The crystal structure of the MgrA homodimer, solved at 2.86 A, indicates the presence of a unique cysteine residue located at the interface of the protein dimer. We discovered that this cysteine residue can be oxidized by various reactive oxygen species, such as hydrogen peroxide and organic hydroperoxide. Cysteine oxidation leads to dissociation of MgrA from DNA and initiation of signaling pathways that turn on antibiotic resistance in S. aureus. The oxidation-sensing mechanism is typically used by bacteria to counter challenges of reactive oxygen and nitrogen species. Our study reveals that in S. aureus, MgrA adopts a similar mechanism but uses it to globally regulate different defensive pathways.
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{{STRUCTURE_2bv6| PDB=2bv6 | SCENE= }}
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An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus.,Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C Nat Chem Biol. 2006 Nov;2(11):591-5. Epub 2006 Sep 17. PMID:16980961<ref>PMID:16980961</ref>
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===CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16980961}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2bv6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BV6 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016980961</ref><references group="xtra"/>
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Bae, T.]]
[[Category: Bae, T.]]

Revision as of 01:54, 30 September 2014

CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS

2bv6, resolution 2.80Å

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