1vcb

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[[Image:1vcb.gif|left|200px]]<br /><applet load="1vcb" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1vcb.gif|left|200px]]
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caption="1vcb, resolution 2.7&Aring;" />
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'''THE VHL-ELONGINC-ELONGINB STRUCTURE'''<br />
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{{Structure
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|PDB= 1vcb |SIZE=350|CAPTION= <scene name='initialview01'>1vcb</scene>, resolution 2.7&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''THE VHL-ELONGINC-ELONGINB STRUCTURE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1VCB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCB OCA].
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1VCB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCB OCA].
==Reference==
==Reference==
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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function., Stebbins CE, Kaelin WG Jr, Pavletich NP, Science. 1999 Apr 16;284(5413):455-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10205047 10205047]
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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function., Stebbins CE, Kaelin WG Jr, Pavletich NP, Science. 1999 Apr 16;284(5413):455-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10205047 10205047]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: ubiquitin]]
[[Category: ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:33:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:43:38 2008''

Revision as of 12:43, 20 March 2008

Image:1vcb.gif


PDB ID 1vcb

Drag the structure with the mouse to rotate
, resolution 2.7Å
Coordinates: save as pdb, mmCIF, xml



THE VHL-ELONGINC-ELONGINB STRUCTURE


Contents

Overview

Mutation of the VHL tumor suppressor is associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC-ElonginB complex and regulates levels of hypoxia-inducible proteins. The structure of the ternary complex at 2.7 angstrom resolution shows two interfaces, one between VHL and ElonginC and another between ElonginC and ElonginB. Tumorigenic mutations frequently occur in a 35-residue domain of VHL responsible for ElonginC binding. A mutational patch on a separate domain of VHL indicates a second macromolecular binding site. The structure extends the similarities to the SCF (Skp1-Cul1-F-box protein) complex that targets proteins for degradation, supporting the hypothesis that VHL may function in an analogous pathway.

Disease

Known diseases associated with this structure: Hemangioblastoma, cerebellar, somatic OMIM:[608537], Pheochromocytoma OMIM:[608537], Polycythemia, benign familial OMIM:[608537], Renal cell carcinoma, somatic OMIM:[608537], von Hippel-Lindau syndrome OMIM:[608537]

About this Structure

1VCB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function., Stebbins CE, Kaelin WG Jr, Pavletich NP, Science. 1999 Apr 16;284(5413):455-61. PMID:10205047

Page seeded by OCA on Thu Mar 20 14:43:38 2008

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