2a3y

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m (Protected "2a3y" [edit=sysop:move=sysop])
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[[Image:2a3y.png|left|200px]]
 
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{{STRUCTURE_2a3y| PDB=2a3y | SCENE= }}
{{STRUCTURE_2a3y| PDB=2a3y | SCENE= }}
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===Pentameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane.===
===Pentameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane.===
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{{ABSTRACT_PUBMED_16036920}}
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{{ABSTRACT_PUBMED_16036920}}
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==Disease==
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[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
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==Function==
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[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016036920</ref><references group="xtra"/>
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<ref group="xtra">PMID:016036920</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bundle, D R.]]
[[Category: Bundle, D R.]]

Revision as of 21:42, 24 March 2013

Template:STRUCTURE 2a3y

Contents

Pentameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane.

Template:ABSTRACT PUBMED 16036920

Disease

[SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Function

[SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

About this Structure

2a3y is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK. Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands. J Biol Chem. 2005 Sep 9;280(36):31999-2008. Epub 2005 Jul 20. PMID:16036920 doi:10.1074/jbc.M504403200

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OCA

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