2ba2

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[[Image:2ba2.png|left|200px]]
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==Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae==
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<StructureSection load='2ba2' size='340' side='right' caption='[[2ba2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ba2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BA2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ba2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ba2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ba2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ba2 PDBsum], [http://www.topsan.org/Proteins/BSGC/2ba2 TOPSAN]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/2ba2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the crystal structure of the DUF16 domain of unknown function encoded by the gene MPN010 of Mycoplasma pneumoniae at 1.8 A resolution. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils. The shorter one consists of 11 highly conserved residues. The sequence comprises noncanonical heptad repeats that induce a right-handed coiled-coil structure. The longer one is composed of approximately nine heptad repeats. In this coiled-coil structure, there are three distinguishable regions that confer unique structural properties compared with other known homotrimeric coiled-coils. The first part, containing one stutter, is an unusual phenylalanine-rich region that is not found in any other coiled-coil structures. The second part is a highly conserved glutamine-rich region, frequently found in other trimeric coiled-coil structures. The last part is composed of prototype heptad repeats. The phylogenetic analysis of the DUF16 family together with a secondary structure prediction shows that the DUF16 family can be classified into five subclasses according to N-terminal sequences. Based on the structural comparison with other coiled-coil structures, a probable molecular function of the DUF16 family is discussed.
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{{STRUCTURE_2ba2| PDB=2ba2 | SCENE= }}
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Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae.,Shin DH, Kim JS, Yokota H, Kim R, Kim SH Protein Sci. 2006 Apr;15(4):921-8. Epub 2006 Mar 7. PMID:16522803<ref>PMID:16522803</ref>
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===Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16522803}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2ba2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BA2 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016522803</ref><references group="xtra"/>
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[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]

Revision as of 02:27, 30 September 2014

Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae

2ba2, resolution 1.80Å

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