1ve6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ve6.gif|left|200px]]<br /><applet load="1ve6" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1ve6.gif|left|200px]]
-
caption="1ve6, resolution 2.1&Aring;" />
+
 
-
'''Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1'''<br />
+
{{Structure
 +
|PDB= 1ve6 |SIZE=350|CAPTION= <scene name='initialview01'>1ve6</scene>, resolution 2.1&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1]
 +
|GENE=
 +
}}
 +
 
 +
'''Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1VE6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix] with <scene name='pdbligand=BOG:'>BOG</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VE6 OCA].
+
1VE6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VE6 OCA].
==Reference==
==Reference==
-
Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1., Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z, Structure. 2004 Aug;12(8):1481-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15296741 15296741]
+
Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1., Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z, Structure. 2004 Aug;12(8):1481-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15296741 15296741]
[[Category: Acylaminoacyl-peptidase]]
[[Category: Acylaminoacyl-peptidase]]
[[Category: Aeropyrum pernix]]
[[Category: Aeropyrum pernix]]
Line 28: Line 37:
[[Category: beta propeller domain]]
[[Category: beta propeller domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:34:18 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:44:19 2008''

Revision as of 12:44, 20 March 2008

Image:1ve6.gif


PDB ID 1ve6

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands: and
Activity: Acylaminoacyl-peptidase, with EC number 3.4.19.1
Coordinates: save as pdb, mmCIF, xml



Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1


Overview

Acylpeptide hydrolases (APH; also known as acylamino acid releasing enzyme) catalyze the removal of an N-acylated amino acid from blocked peptides. The crystal structure of an APH from the thermophilic archaeon Aeropyrum pernix K1 to 2.1 A resolution confirms it to be a member of the prolyl oligopeptidase family of serine proteases. The structure of apAPH is a symmetric homodimer with each subunit comprised of two domains. The N-terminal domain is a regular seven-bladed beta-propeller, while the C-terminal domain has a canonical alpha/beta hydrolase fold and includes the active site and a conserved Ser445-Asp524-His556 catalytic triad. The complex structure of apAPH with an organophosphorus substrate, p-nitrophenyl phosphate, has also been determined. The complex structure unambiguously maps out the substrate binding pocket and provides a basis for substrate recognition by apAPH. A conserved mechanism for protein degradation from archaea to mammals is suggested by the structural features of apAPH.

About this Structure

1VE6 is a Single protein structure of sequence from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1., Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z, Structure. 2004 Aug;12(8):1481-8. PMID:15296741

Page seeded by OCA on Thu Mar 20 14:44:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ve6"
Personal tools