2bfi

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[[Image:2bfi.png|left|200px]]
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==MOLECULAR BASIS FOR AMYLOID FIBRIL FORMATION AND STABILITY==
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<StructureSection load='2bfi' size='340' side='right' caption='[[2bfi]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bfi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BFI FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bfi RCSB], [http://www.ebi.ac.uk/pdbsum/2bfi PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The molecular structure of the amyloid fibril has remained elusive because of the difficulty of growing well diffracting crystals. By using a sequence-designed polypeptide, we have produced crystals of an amyloid fiber. These crystals diffract to high resolution (1 A) by electron and x-ray diffraction, enabling us to determine a detailed structure for amyloid. The structure reveals that the polypeptides form fibrous crystals composed of antiparallel beta-sheets in a cross-beta arrangement, characteristic of all amyloid fibers, and allows us to determine the side-chain packing within an amyloid fiber. The antiparallel beta-sheets are zipped together by means of pi-bonding between adjacent phenylalanine rings and salt-bridges between charge pairs (glutamic acid-lysine), thus controlling and stabilizing the structure. These interactions are likely to be important in the formation and stability of other amyloid fibrils.
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{{STRUCTURE_2bfi| PDB=2bfi | SCENE= }}
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Molecular basis for amyloid fibril formation and stability.,Makin OS, Atkins E, Sikorski P, Johansson J, Serpell LC Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20. Epub 2005 Jan 3. PMID:15630094<ref>PMID:15630094</ref>
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===MOLECULAR BASIS FOR AMYLOID FIBRIL FORMATION AND STABILITY===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15630094}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2bfi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFI OCA].
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</StructureSection>
[[Category: Atkins, E.]]
[[Category: Atkins, E.]]
[[Category: Johansson, J.]]
[[Category: Johansson, J.]]

Revision as of 08:27, 8 October 2014

MOLECULAR BASIS FOR AMYLOID FIBRIL FORMATION AND STABILITY

2bfi, resolution 1.10Å

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