1dy6
From Proteopedia
(New page: 200px<br /> <applet load="1dy6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dy6, resolution 2.13Å" /> '''STRUCTURE OF THE IM...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1DY6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]]. | + | 1DY6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]]. Structure known Active Sites: ASA and ASB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DY6 OCA]]. |
==Reference== | ==Reference== | ||
| Line 28: | Line 28: | ||
[[Category: lactamase]] | [[Category: lactamase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:34:45 2007'' |
Revision as of 06:30, 30 October 2007
|
STRUCTURE OF THE IMIPENEM-HYDROLYZING BETA-LACTAMASE SME-1
Overview
The structure of the beta-lactamase SME-1 from Serratia marcescens, a, class A enzyme characterized by its significant activity against imipenem, has been determined to 2.13 A resolution. The overall structure of SME-1, is similar to that of other class A beta-lactamases. In the active-site, cavity, most of the residues found in SME-1 are conserved among class A, beta-lactamases, except at positions 104, 105 and 237, where a tyrosine, a, histidine and a serine are found, respectively, and at position 238, which, is occupied by a cysteine forming a disulfide bridge with the other, cysteine residue located at position 69. The crucial role played by this, disulfide bridge in SME-1 was confirmed by site-directed mutagenesis of, Cys69 to Ala, which resulted in a mutant unable to confer ... [(full description)]
About this Structure
1DY6 is a [Single protein] structure of sequence from [Serratia marcescens]. Active as [Hydrolase], with EC number [3.5.2.6]. Structure known Active Sites: ASA and ASB. Full crystallographic information is available from [OCA].
Reference
Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1 from Serratia marcescens., Sougakoff W, L'Hermite G, Pernot L, Naas T, Guillet V, Nordmann P, Jarlier V, Delettre J, Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):267-74. Epub 2002, Jan 24. PMID:11807251
Page seeded by OCA on Tue Oct 30 08:34:45 2007
