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2kdr

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[[Image:2kdr.png|left|200px]]
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==Solution structure of HCV NS4B(227-254)==
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<StructureSection load='2kdr' size='340' side='right' caption='[[2kdr]], [[NMR_Ensembles_of_Models | 27 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kdr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KDR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jxf|2jxf]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kdr RCSB], [http://www.ebi.ac.uk/pdbsum/2kdr PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nonstructural protein 4B (NS4B) plays an essential role in the formation of the hepatitis C virus (HCV) replication complex. It is an integral membrane protein that has been only poorly characterized to date. It is believed to comprise a cytosolic N-terminal part, a central part harboring four transmembrane passages, and a cytosolic C-terminal part. Here, we describe an amphipathic alpha-helix at the C terminus of NS4B (amino acid residues 229 to 253) that mediates membrane association and is involved in the formation of a functional HCV replication complex.
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{{STRUCTURE_2kdr| PDB=2kdr | SCENE= }}
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An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association.,Gouttenoire J, Montserret R, Kennel A, Penin F, Moradpour D J Virol. 2009 Nov;83(21):11378-84. Epub 2009 Aug 19. PMID:19692468<ref>PMID:19692468</ref>
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===Solution structure of HCV NS4B(227-254)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19692468}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kdr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDR OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019692468</ref><references group="xtra"/>
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[[Category: Montserret, R.]]
[[Category: Montserret, R.]]
[[Category: Penin, F.]]
[[Category: Penin, F.]]

Revision as of 15:36, 12 October 2014

Solution structure of HCV NS4B(227-254)

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