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2pot

From Proteopedia

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[[Image:2pot.png|left|200px]]
 
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{{STRUCTURE_2pot| PDB=2pot | SCENE= }}
{{STRUCTURE_2pot| PDB=2pot | SCENE= }}
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===tRNA guanine transglycosylase (TGT) E235Q mutant in complex with guanine===
===tRNA guanine transglycosylase (TGT) E235Q mutant in complex with guanine===
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{{ABSTRACT_PUBMED_17949745}}
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{{ABSTRACT_PUBMED_17949745}}
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==Function==
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[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017949745</ref><references group="xtra"/>
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<ref group="xtra">PMID:017949745</ref><references group="xtra"/><references/>
[[Category: Zymomonas mobilis]]
[[Category: Zymomonas mobilis]]
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[[Category: TRNA-guanine transglycosylase]]
 
[[Category: Heine, A.]]
[[Category: Heine, A.]]
[[Category: Klebe, G.]]
[[Category: Klebe, G.]]

Revision as of 10:06, 24 April 2013

Template:STRUCTURE 2pot

Contents

tRNA guanine transglycosylase (TGT) E235Q mutant in complex with guanine

Template:ABSTRACT PUBMED 17949745

Function

[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

About this Structure

2pot is a 1 chain structure with sequence from Zymomonas mobilis. Full crystallographic information is available from OCA.

Reference

  • Tidten N, Stengl B, Heine A, Garcia GA, Klebe G, Reuter K. Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies. J Mol Biol. 2007 Nov 30;374(3):764-76. Epub 2007 Oct 22. PMID:17949745 doi:10.1016/j.jmb.2007.09.062

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OCA

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