2jq3

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[[Image:2jq3.png|left|200px]]
 
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{{STRUCTURE_2jq3| PDB=2jq3 | SCENE= }}
{{STRUCTURE_2jq3| PDB=2jq3 | SCENE= }}
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===Structure and Dynamics of Human Apolipoprotein C-III===
===Structure and Dynamics of Human Apolipoprotein C-III===
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{{ABSTRACT_PUBMED_18408013}}
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{{ABSTRACT_PUBMED_18408013}}
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==Disease==
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[[http://www.uniprot.org/uniprot/APOC3_HUMAN APOC3_HUMAN]] Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2) [MIM:[http://omim.org/entry/614028 614028]]. HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.<ref>PMID:2022742</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/APOC3_HUMAN APOC3_HUMAN]] Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:018408013</ref><references group="xtra"/>
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<ref group="xtra">PMID:018408013</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gangabadage, C S.]]
[[Category: Gangabadage, C S.]]

Revision as of 10:33, 24 March 2013

Template:STRUCTURE 2jq3

Contents

Structure and Dynamics of Human Apolipoprotein C-III

Template:ABSTRACT PUBMED 18408013

Disease

[APOC3_HUMAN] Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2) [MIM:614028]. HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.[1]

Function

[APOC3_HUMAN] Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

About this Structure

2jq3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Gangabadage CS, Zdunek J, Tessari M, Nilsson S, Olivecrona G, Wijmenga SS. Structure and dynamics of human apolipoprotein CIII. J Biol Chem. 2008 Jun 20;283(25):17416-27. Epub 2008 Apr 11. PMID:18408013 doi:10.1074/jbc.M800756200
  1. ↑ von Eckardstein A, Holz H, Sandkamp M, Weng W, Funke H, Assmann G. Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. J Clin Invest. 1991 May;87(5):1724-31. PMID:2022742 doi:http://dx.doi.org/10.1172/JCI115190

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