2keg

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[[Image:2keg.png|left|200px]]
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==NMR structure of Plantaricin K in DPC-micelles==
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<StructureSection load='2keg' size='340' side='right' caption='[[2keg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2keg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KEG FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2keg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2keg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2keg RCSB], [http://www.ebi.ac.uk/pdbsum/2keg PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structures of the two peptides, PlnJ and PlnK, that constitutes the two-peptide bacteriocin plantaricin JK have been solved in water/TFE and water/DPC-micellar solutions using nuclear magnetic resonance (NMR) spectroscopy. PlnJ, a 25 residue peptide, has an N-terminal amphiphilic alpha-helix between Trp-3 and Tyr-15. The 32 residues long PlnK forms a central amphiphilic alpha-helix between Gly-9 and Leu-24. Measurements of the effect on anti-microbial activity of single glycine replacements in PlnJ and PlnK show that Gly-13 and Gly-17 in both peptides are very sensitive, giving more than a 100-fold reduction in activity when large residues replace glycine. In variants where other glycine residues, Gly-20 in PlnJ and Gly-7, Gly-9, Gly-24 and Gly-25 in PlnK, were replaced, the activity was reduced less than 10-fold. It is proposed that the detrimental effect on activity when exchanging Gly-13 and Gly-17 in PlnJ and PlnK is a result of reduced ability of the two peptides to interact through the GxxxG-motifs constituting Gly-13 and Gly-17.
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{{STRUCTURE_2keg| PDB=2keg | SCENE= }}
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Three-dimensional structure of the two-peptide bacteriocin plantaricin JK.,Rogne P, Haugen C, Fimland G, Nissen-Meyer J, Kristiansen PE Peptides. 2009 Sep;30(9):1613-21. Epub 2009 Jun 16. PMID:19538999<ref>PMID:19538999</ref>
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===NMR structure of Plantaricin K in DPC-micelles===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19538999}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2keg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KEG OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019538999</ref><references group="xtra"/>
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[[Category: Fimland, G.]]
[[Category: Fimland, G.]]
[[Category: Haugen, M.]]
[[Category: Haugen, M.]]

Revision as of 15:27, 12 October 2014

NMR structure of Plantaricin K in DPC-micelles

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