2kmj

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[[Image:2kmj.png|left|200px]]
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==High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry==
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<StructureSection load='2kmj' size='340' side='right' caption='[[2kmj]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kmj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KMJ FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZUK:5-PYRIMIDIN-2-YL-D-NORVALINE'>ZUK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kmj RCSB], [http://www.ebi.ac.uk/pdbsum/2kmj PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.
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{{STRUCTURE_2kmj| PDB=2kmj | SCENE= }}
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Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830<ref>PMID:19444830</ref>
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===High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19444830}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kmj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019444830</ref><references group="xtra"/>
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[[Category: Human immunodeficiency virus 2]]
[[Category: Human immunodeficiency virus 2]]
[[Category: Breitung, S.]]
[[Category: Breitung, S.]]

Revision as of 15:29, 12 October 2014

High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry

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