1vs2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1vs2.gif|left|200px]]<br /><applet load="1vs2" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1vs2.gif|left|200px]]
-
caption="1vs2, resolution 2.000&Aring;" />
+
 
-
'''Interactions of quinoxaline antibiotic and DNA: the molecular structure of a TRIOSTIN A-D(GCGTACGC) complex'''<br />
+
{{Structure
 +
|PDB= 1vs2 |SIZE=350|CAPTION= <scene name='initialview01'>1vs2</scene>, resolution 2.000&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=QUI:2-CARBOXYQUINOXALINE'>QUI</scene>, <scene name='pdbligand=NCY:N-METHYLCYSTEINE'>NCY</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene> and <scene name='pdbligand=ALA:ALANINE'>ALA</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''Interactions of quinoxaline antibiotic and DNA: the molecular structure of a TRIOSTIN A-D(GCGTACGC) complex'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1VS2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=QUI:'>QUI</scene>, <scene name='pdbligand=NCY:'>NCY</scene>, <scene name='pdbligand=MVA:'>MVA</scene>, <scene name='pdbligand=SER:'>SER</scene> and <scene name='pdbligand=ALA:'>ALA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VS2 OCA].
+
1VS2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VS2 OCA].
==Reference==
==Reference==
-
Interactions of quinoxaline antibiotic and DNA: the molecular structure of a triostin A-d(GCGTACGC) complex., Wang AH, Ughetto G, Quigley GJ, Rich A, J Biomol Struct Dyn. 1986 Dec;4(3):319-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=3271447 3271447]
+
Interactions of quinoxaline antibiotic and DNA: the molecular structure of a triostin A-d(GCGTACGC) complex., Wang AH, Ughetto G, Quigley GJ, Rich A, J Biomol Struct Dyn. 1986 Dec;4(3):319-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3271447 3271447]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Quigley, G J.]]
[[Category: Quigley, G J.]]
Line 25: Line 34:
[[Category: right handed dna]]
[[Category: right handed dna]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:38:02 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:48:58 2008''

Revision as of 12:48, 20 March 2008

Image:1vs2.gif


PDB ID 1vs2

Drag the structure with the mouse to rotate
, resolution 2.000Å
Ligands: , , , and
Coordinates: save as pdb, mmCIF, xml



Interactions of quinoxaline antibiotic and DNA: the molecular structure of a TRIOSTIN A-D(GCGTACGC) complex


Overview

The crystal structure of a DNA octamer d(GCGTACGC) complexed to an antitumor antibiotic, triostin A, has been solved and refined to 2.2 A resolution by x-ray diffraction analysis. The antibiotic molecule acts as a true bis intercalator surrounding the d(CpG) sequence at either end of the unwound right-handed DNA double helix. As previously observed in the structure of triostin A-d(CGTACG) complex (A.H.-J. Wang, et. al., Science, 225, 1115-1121 (1984)), the alanine amino acid residues of the drug molecule form sequence-specific hydrogen bonds to guanines in the minor groove. The two central A.T base pairs are in Hoogsteen configuration with adenine in the syn conformation. In addition, the two terminal G.C base pairs flanking the quinoxaline rings are also held together by Hoogsteen base pairing. This is the first observation in an oligonucleotide of. Hoogsteen G.C base pairs where the cytosine is protonated. The principal functional components of a bis-intercalative compound are discussed.

About this Structure

1VS2 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Interactions of quinoxaline antibiotic and DNA: the molecular structure of a triostin A-d(GCGTACGC) complex., Wang AH, Ughetto G, Quigley GJ, Rich A, J Biomol Struct Dyn. 1986 Dec;4(3):319-42. PMID:3271447

Page seeded by OCA on Thu Mar 20 14:48:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vs2"
Personal tools