2hp4

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[[Image:2hp4.png|left|200px]]
 
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{{STRUCTURE_2hp4| PDB=2hp4 | SCENE= }}
{{STRUCTURE_2hp4| PDB=2hp4 | SCENE= }}
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===Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor===
===Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor===
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{{ABSTRACT_PUBMED_17243170}}
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{{ABSTRACT_PUBMED_17243170}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN]] Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:[http://omim.org/entry/608957 608957]]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
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==Function==
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[[http://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN]] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017243170</ref><references group="xtra"/>
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<ref group="xtra">PMID:017243170</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boulter, J M.]]
[[Category: Boulter, J M.]]

Revision as of 11:52, 24 March 2013

Template:STRUCTURE 2hp4

Contents

Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor

Template:ABSTRACT PUBMED 17243170

Disease

[CD8A_HUMAN] Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

Function

[CD8A_HUMAN] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

About this Structure

2hp4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Cole DK, Rizkallah PJ, Boulter JM, Sami M, Vuidepot AL, Glick M, Gao F, Bell JI, Jakobsen BK, Gao GF. Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor. Proteins. 2007 Apr 1;67(1):65-74. PMID:17243170 doi:10.1002/prot.21176

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OCA

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