2hrv

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[[Image:2hrv.png|left|200px]]
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==2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2==
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<StructureSection load='2hrv' size='340' side='right' caption='[[2hrv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2hrv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_a2 Human rhinovirus a2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HRV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Picornain_2A Picornain 2A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.29 3.4.22.29] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hrv RCSB], [http://www.ebi.ac.uk/pdbsum/2hrv PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/2hrv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2-2A(pro)) has been solved to 1.95 A resolution. The structure has an unusual, although chymotrypsin-related, fold comprising a unique four-stranded beta sheet as the N-terminal domain and a six-stranded beta barrel as the C-terminal domain. A tightly bound zinc ion, essential for the stability of HRV2-2A(pro), is tetrahedrally coordinated by three cysteine sulfurs and one histidine nitrogen. The active site consists of a catalytic triad formed by His18, Asp35 and Cys106. Asp35 is additionally involved in an extensive hydrogen-bonding network. Modelling studies reveal a substrate-induced fit that explains the specificity of the subsites S4, S2, S1 and S1'. The structure of HRV2-2A(pro) suggests the mechanism of the cis cleavage and its release from the polyprotein.
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{{STRUCTURE_2hrv| PDB=2hrv | SCENE= }}
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The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.,Petersen JF, Cherney MM, Liebig HD, Skern T, Kuechler E, James MN EMBO J. 1999 Oct 15;18(20):5463-75. PMID:10523291<ref>PMID:10523291</ref>
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===2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_10523291}}
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==See Also==
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*[[Proteinase|Proteinase]]
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==About this Structure==
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== References ==
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[[2hrv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_a2 Human rhinovirus a2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRV OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010523291</ref><references group="xtra"/>
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[[Category: Human rhinovirus a2]]
[[Category: Human rhinovirus a2]]
[[Category: Picornain 2A]]
[[Category: Picornain 2A]]

Revision as of 09:14, 3 October 2014

2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2

2hrv, resolution 1.95Å

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