2pfc

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[[Image:2pfc.png|left|200px]]
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==Structure of Mycobacterium tuberculosis Rv0098==
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<StructureSection load='2pfc' size='340' side='right' caption='[[2pfc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2pfc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PFC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pfc RCSB], [http://www.ebi.ac.uk/pdbsum/2pfc PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rv0098 is part of an operon, Rv0096-Rv0101, from Mycobacterium tuberculosis (Mtb) that is essential for Mtb's survival in mouse macrophages. This operon also contains an acyl carrier protein and one of the only two nonribosomal peptide synthases in Mtb. Rv0098 is annotated in the genome as a hypothetical protein and was proposed to be an acyl-coenzyme A (CoA) dehydratase. The structure of Rv0098, together with subsequent biochemical analysis, indicated that Rv0098 is a long-chain fatty acyl-CoA thioesterase (FcoT). However, FcoT lacks a general base or a nucleophile that is always found in the catalytic site of type II and type I thioesterases, respectively. The active site of Mtb FcoT reveals the structural basis for its substrate specificity for long-chain acyl-CoA and allows us to propose a catalytic mechanism for the enzyme. The characterization of Mtb FcoT provides a putative function of this operon that is crucial for Mtb pathogenicity.
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{{STRUCTURE_2pfc| PDB=2pfc | SCENE= }}
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Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.,Wang F, Langley R, Gulten G, Wang L, Sacchettini JC Chem Biol. 2007 May;14(5):543-51. PMID:17524985<ref>PMID:17524985</ref>
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===Structure of Mycobacterium tuberculosis Rv0098===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17524985}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2pfc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFC OCA].
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</StructureSection>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Sacchettini, J C.]]
[[Category: Sacchettini, J C.]]

Revision as of 11:26, 20 October 2014

Structure of Mycobacterium tuberculosis Rv0098

2pfc, resolution 2.30Å

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