2kv6

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[[Image:2kv6.png|left|200px]]
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==Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether==
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<StructureSection load='2kv6' size='340' side='right' caption='[[2kv6]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kv6]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KV6 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0AD:2-DEOXY-N-PROPYLGUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>0AD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/2kv6 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DNA-protein conjugates are potentially repaired via proteolytic digestion to DNA-peptide conjugates. The latter have been modeled with the amino-terminal lysine of the peptide KWKK conjugated via a trimethylene linkage to the N(2)-dG amine positioned in 5'-d(GCTAGCXAGTCC)-3'.5'-d(GGACTCGCTAGC)-3' (X = N(2)-dG-trimethylene link-KWKK). This linkage is a surrogate for the reversible linkage formed by the gamma-OH-1,N(2)-propanodeoxyguanosine (gamma-OH-PdG) adduct. This conjugated KWKK stabilizes the DNA. Amino acids K(26), W(27), K(28), and K(29) are in the minor groove. The W(27) indolyl group does not intercalate into the DNA. The G(7) N(2) amine and the K(26) N-terminal amine nitrogens are in the trans configuration with respect to the C(alpha) or C(gamma) of the trimethylene tether, respectively. The structure of this DNA-KWKK conjugate is discussed in the context of its biological processing.
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{{STRUCTURE_2kv6| PDB=2kv6 | SCENE= }}
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Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,N(2)-gamma-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage .,Huang H, Kozekov ID, Kozekova A, Rizzo CJ, McCullough AK, Lloyd RS, Stone MP Biochemistry. 2010 Jul 6. PMID:20604523<ref>PMID:20604523</ref>
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===Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20604523}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kv6]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV6 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020604523</ref><references group="xtra"/>
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[[Category: Huang, H.]]
[[Category: Huang, H.]]
[[Category: Kozekov, I D.]]
[[Category: Kozekov, I D.]]

Revision as of 15:36, 12 October 2014

Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether

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