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1w50
From Proteopedia
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| - | [[Image:1w50.gif|left|200px]] | + | [[Image:1w50.gif|left|200px]] |
| - | + | ||
| - | '''APO STRUCTURE OF BACE (BETA SECRETASE)''' | + | {{Structure |
| + | |PDB= 1w50 |SIZE=350|CAPTION= <scene name='initialview01'>1w50</scene>, resolution 1.75Å | ||
| + | |SITE= <scene name='pdbsite=AC2:Iod+Binding+Site+For+Chain+A'>AC2</scene> | ||
| + | |LIGAND= <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''APO STRUCTURE OF BACE (BETA SECRETASE)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W50 is a [ | + | 1W50 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W50 OCA]. |
==Reference== | ==Reference== | ||
| - | Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:[http:// | + | Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15451669 15451669] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:52:23 2008'' |
Revision as of 12:52, 20 March 2008
| |||||||
| , resolution 1.75Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | |||||||
| Activity: | Memapsin 2, with EC number 3.4.23.46 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
APO STRUCTURE OF BACE (BETA SECRETASE)
Overview
Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.
About this Structure
1W50 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669
Page seeded by OCA on Thu Mar 20 14:52:23 2008
