1w4v
From Proteopedia
Line 1: | Line 1: | ||
- | [[Image:1w4v.gif|left|200px]] | + | [[Image:1w4v.gif|left|200px]] |
- | + | ||
- | '''STRUCTURE OF THE OXIDISED FORM OF HUMAN THIOREDOXIN 2''' | + | {{Structure |
+ | |PDB= 1w4v |SIZE=350|CAPTION= <scene name='initialview01'>1w4v</scene>, resolution 1.80Å | ||
+ | |SITE= <scene name='pdbsite=TRX:Active+Site'>TRX</scene> | ||
+ | |LIGAND= | ||
+ | |ACTIVITY= | ||
+ | |GENE= | ||
+ | }} | ||
+ | |||
+ | '''STRUCTURE OF THE OXIDISED FORM OF HUMAN THIOREDOXIN 2''' | ||
+ | |||
==Overview== | ==Overview== | ||
Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
- | 1W4V is a [ | + | 1W4V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4V OCA]. |
==Reference== | ==Reference== | ||
- | Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2., Smeets A, Evrard C, Landtmeters M, Marchand C, Knoops B, Declercq JP, Protein Sci. 2005 Oct;14(10):2610-21. PMID:[http:// | + | Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2., Smeets A, Evrard C, Landtmeters M, Marchand C, Knoops B, Declercq JP, Protein Sci. 2005 Oct;14(10):2610-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16195549 16195549] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
Line 22: | Line 31: | ||
[[Category: thioredoxin]] | [[Category: thioredoxin]] | ||
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:52:11 2008'' |
Revision as of 12:52, 20 March 2008
| |||||||
, resolution 1.80Å | |||||||
---|---|---|---|---|---|---|---|
Sites: | |||||||
Coordinates: | save as pdb, mmCIF, xml |
STRUCTURE OF THE OXIDISED FORM OF HUMAN THIOREDOXIN 2
Overview
Mammalian thioredoxin 2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions. In mammals, thioredoxin 2 is encoded by a nuclear gene and is targeted to mitochondria by a N-terminal mitochondrial presequence. Recently, mitochondrial thioredoxin 2 was shown to interact with components of the mitochondrial respiratory chain and to play a role in the control of mitochondrial membrane potential, regulating mitochondrial apoptosis signaling pathway. Here we report the first crystal structures of a mammalian mitochondrial thioredoxin 2. Crystal forms of reduced and oxidized human thioredoxin 2 are described at 2.0 and 1.8 A resolution. Though the folding is rather similar to that of human cytosolic/nuclear thioredoxin 1, important differences are observed during the transition between the oxidized and the reduced states of human thioredoxin 2, compared with human thioredoxin 1. In spite of the absence of the Cys residue implicated in dimer formation in human thioredoxin 1, dimerization still occurs in the crystal structure of human thioredoxin 2, mainly mediated by hydrophobic contacts, and the dimers are associated to form two-dimensional polymers. Interestingly, the structure of human thioredoxin 2 reveals possible interaction domains with human peroxiredoxin 5, a substrate protein of human thioredoxin 2 in mitochondria.
About this Structure
1W4V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2., Smeets A, Evrard C, Landtmeters M, Marchand C, Knoops B, Declercq JP, Protein Sci. 2005 Oct;14(10):2610-21. PMID:16195549
Page seeded by OCA on Thu Mar 20 14:52:11 2008