2hac
From Proteopedia
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| - | [[Image:2hac.png|left|200px]] | ||
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{{STRUCTURE_2hac| PDB=2hac | SCENE= }} | {{STRUCTURE_2hac| PDB=2hac | SCENE= }} | ||
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===Structure of Zeta-Zeta Transmembrane Dimer=== | ===Structure of Zeta-Zeta Transmembrane Dimer=== | ||
| + | {{ABSTRACT_PUBMED_17055436}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[http://omim.org/entry/610163 610163]]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref> | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:017055436</ref><references group="xtra"/> | + | <ref group="xtra">PMID:017055436</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Call, M E.]] | [[Category: Call, M E.]] | ||
Revision as of 17:14, 24 March 2013
Contents |
Structure of Zeta-Zeta Transmembrane Dimer
Template:ABSTRACT PUBMED 17055436
Disease
[CD3Z_HUMAN] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.[1]
Function
[CD3Z_HUMAN] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
About this Structure
2hac is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006 Oct 20;127(2):355-68. PMID:17055436 doi:10.1016/j.cell.2006.08.044
- ↑ Rieux-Laucat F, Hivroz C, Lim A, Mateo V, Pellier I, Selz F, Fischer A, Le Deist F. Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med. 2006 May 4;354(18):1913-21. PMID:16672702 doi:354/18/1913
