2fo7

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[[Image:2fo7.png|left|200px]]
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==Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)==
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<StructureSection load='2fo7' size='340' side='right' caption='[[2fo7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fo7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FO7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2avp|2avp]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fo7 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/2fo7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure and stability of repeat proteins has been little studied in comparison to the properties of the more familiar globular proteins. Here, the structure and stability of designed tetratricopeptide-repeat (TPR) proteins is described. The TPR is a 34-amino-acid motif which adopts a helix-turn-helix structure and occurs as tandem repeats. The design of a consensus TPR motif (CTPR) has previously been described. Here, the crystal structures and stabilities of proteins that contain eight or 20 identical tandem repeats of the CTPR motif (CTPR8 and CTPR20) are presented. Both CTPR8 and CTPR20 adopt a superhelical overall structure. The structures of the different-length CTPR proteins are compared with each other and with the structures of natural TPR domains. Also, the unusual and perhaps unique crystal-packing interactions resulting in pseudo-infinite crystalline superhelices observed in the different crystal forms of CTPR8 and CTPR20 are discussed. Finally, it is shown that the thermodynamic behavior of CTPR8 and CTPR20 can be predicted from the behavior of other TPRs in this series using an Ising model-based analysis. The designed protein series CTPR2-CTPR20 covers the natural size repertoire of TPR domains and as such is an excellent model system for natural TPR proteins.
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{{STRUCTURE_2fo7| PDB=2fo7 | SCENE= }}
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Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins.,Kajander T, Cortajarena AL, Mochrie S, Regan L Acta Crystallogr D Biol Crystallogr. 2007 Jul;63(Pt 7):800-11. Epub 2007, Jun 15. PMID:17582171<ref>PMID:17582171</ref>
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===Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17582171}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2fo7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FO7 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017582171</ref><references group="xtra"/>
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[[Category: Cortajarena, A L.]]
[[Category: Cortajarena, A L.]]
[[Category: Kajander, T.]]
[[Category: Kajander, T.]]

Revision as of 10:49, 30 September 2014

Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)

2fo7, resolution 2.30Å

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