This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2mag

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2mag" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2mag.png|left|200px]]
+
==NMR STRUCTURE OF MAGAININ 2 IN DPC MICELLES, 10 STRUCTURES==
 +
<StructureSection load='2mag' size='340' side='right' caption='[[2mag]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2mag]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MAG FirstGlance]. <br>
 +
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mag OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mag RCSB], [http://www.ebi.ac.uk/pdbsum/2mag PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Magainin2 is a 23-residue antibiotic peptide that disrupts the ionic gradient across certain cell membranes. Two-dimensional 1H NMR spectroscopy was used to investigate the structure of the peptide in three of the membrane environments most commonly employed in biophysical studies. Sequence-specific resonance assignments were determined for the peptide in perdeuterated dodecylphosphocholine (DPC) and sodium dodecylsulfate micelles and confirmed for the peptide in 2,2,2-trifluoroethanol solution. The secondary structure is shown to be helical in all of the solvent systems. The NMR data were used as a set of restraints for a simulated annealing protocol that generated a family of three-dimensional structures of the peptide in DPC micelles, which superimposed best between residues 4 and 20. For these residues, the mean pairwise rms difference for the backbone atoms is 0.47 +/- 0.10 A from the average structure. The calculated peptide structures appear to be curved, with the bend centered at residues Phe12 and Gly13.
-
{{STRUCTURE_2mag| PDB=2mag | SCENE= }}
+
Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution.,Gesell J, Zasloff M, Opella SJ J Biomol NMR. 1997 Feb;9(2):127-35. PMID:9090128<ref>PMID:9090128</ref>
-
===NMR STRUCTURE OF MAGAININ 2 IN DPC MICELLES, 10 STRUCTURES===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_9090128}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2mag]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAG OCA].
+
</StructureSection>
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Gesell, J J.]]
[[Category: Gesell, J J.]]

Revision as of 11:25, 20 October 2014

NMR STRUCTURE OF MAGAININ 2 IN DPC MICELLES, 10 STRUCTURES

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mag"
Personal tools