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1wq6

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[[Image:1wq6.gif|left|200px]]<br /><applet load="1wq6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1wq6.gif|left|200px]]
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caption="1wq6, resolution 2.00&Aring;" />
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'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''<br />
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{{Structure
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|PDB= 1wq6 |SIZE=350|CAPTION= <scene name='initialview01'>1wq6</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= AML1/ETO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1WQ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ6 OCA].
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1WQ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ6 OCA].
==Reference==
==Reference==
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The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16616331 16616331]
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The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16616331 16616331]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: nhr2]]
[[Category: nhr2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:47:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:00:13 2008''

Revision as of 13:00, 20 March 2008

Image:1wq6.gif


PDB ID 1wq6

Drag the structure with the mouse to rotate
, resolution 2.00Å
Gene: AML1/ETO (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity


Overview

AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.

About this Structure

1WQ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:16616331

Page seeded by OCA on Thu Mar 20 15:00:13 2008

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