2omj

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[[Image:2omj.png|left|200px]]
 
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{{STRUCTURE_2omj| PDB=2omj | SCENE= }}
{{STRUCTURE_2omj| PDB=2omj | SCENE= }}
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===solution structure of LARG PDZ domain===
===solution structure of LARG PDZ domain===
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{{ABSTRACT_PUBMED_018411422}}
{{ABSTRACT_PUBMED_018411422}}
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==Disease==
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[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.
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==Function==
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[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref>
==About this Structure==
==About this Structure==
[[2omj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMJ OCA].
[[2omj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMJ OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hu, Q.]]
[[Category: Hu, Q.]]

Revision as of 05:39, 25 March 2013

Template:STRUCTURE 2omj

Contents

solution structure of LARG PDZ domain

Template:ABSTRACT PUBMED 018411422

Disease

[ARHGC_HUMAN] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.

Function

[ARHGC_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.[1]

About this Structure

2omj is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. ↑ Fukuhara S, Chikumi H, Gutkind JS. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. FEBS Lett. 2000 Nov 24;485(2-3):183-8. PMID:11094164

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