2nso
From Proteopedia
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{{STRUCTURE_2nso| PDB=2nso | SCENE= }} | {{STRUCTURE_2nso| PDB=2nso | SCENE= }} | ||
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===Trna-gunanine-transglycosylase (TGT) mutant Y106F, C158V, A232S, V233G- APO-Structure=== | ===Trna-gunanine-transglycosylase (TGT) mutant Y106F, C158V, A232S, V233G- APO-Structure=== | ||
| + | {{ABSTRACT_PUBMED_23704982}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
==About this Structure== | ==About this Structure== | ||
[[2nso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSO OCA]. | [[2nso]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSO OCA]. | ||
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| + | ==See Also== | ||
| + | *[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023704982</ref><references group="xtra"/><references/> | ||
[[Category: Zymomonas mobilis]] | [[Category: Zymomonas mobilis]] | ||
| - | [[Category: TRNA-guanine transglycosylase]] | ||
[[Category: Heine, A.]] | [[Category: Heine, A.]] | ||
[[Category: Klebe, G.]] | [[Category: Klebe, G.]] | ||
Revision as of 04:35, 18 July 2013
Contents |
Trna-gunanine-transglycosylase (TGT) mutant Y106F, C158V, A232S, V233G- APO-Structure
Template:ABSTRACT PUBMED 23704982
Function
[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
About this Structure
2nso is a 1 chain structure with sequence from Zymomonas mobilis. Full crystallographic information is available from OCA.
See Also
Reference
- Biela I, Tidten-Luksch N, Immekus F, Glinca S, Nguyen TX, Gerber HD, Heine A, Klebe G, Reuter K. Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor. PLoS One. 2013 May 21;8(5):e64240. doi: 10.1371/journal.pone.0064240. Print 2013. PMID:23704982 doi:10.1371/journal.pone.0064240
