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2kpr

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[[Image:2kpr.png|left|200px]]
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==Monomeric intronic human chl1 gene quadruplex DNA NMR, 17 structures==
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<StructureSection load='2kpr' size='340' side='right' caption='[[2kpr]], [[NMR_Ensembles_of_Models | 17 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kpr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KPR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u64|1u64]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kpr RCSB], [http://www.ebi.ac.uk/pdbsum/2kpr PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report on the solution structure of an unprecedented intramolecular G-quadruplex formed by the guanosine-rich human chl1 intronic d(G(3)-N-G(4)-N(2)-G(4)-N-G(3)-N) 19-mer sequence in K(+)-containing solution. This G-quadruplex, composed of three stacked G-tetrads containing four syn guanines, represents a new folding topology with two unique conformational features. The first guanosine is positioned within the central G-tetrad, in contrast to all previous structures of unimolecular G-quadruplexes, where the first guanosine is part of an outermost G-tetrad. In addition, a V-shaped loop, spanning three G-tetrad planes, contains no bridging nucleotides. The G-quadruplex scaffold is stabilized by a T*G*A triple stacked over the G-tetrad at one end and an unpaired guanosine stacked over the G-tetrad at the other end. Finally, the chl1 intronic DNA G-quadruplex scaffold contains a guanosine base intercalated between an extended G-G step, a feature observed in common with the catalytic site of group I introns. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to intronic G-quadruplex platforms.
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{{STRUCTURE_2kpr| PDB=2kpr | SCENE= }}
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Solution structure of a unique G-quadruplex scaffold adopted by a guanosine-rich human intronic sequence.,Kuryavyi V, Patel DJ Structure. 2010 Jan 13;18(1):73-82. PMID:20152154<ref>PMID:20152154</ref>
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===Monomeric intronic human chl1 gene quadruplex DNA NMR, 17 structures===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20152154}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kpr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPR OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020152154</ref><references group="xtra"/>
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[[Category: Kuryavyi, V.]]
[[Category: Kuryavyi, V.]]
[[Category: Patel, D J.]]
[[Category: Patel, D J.]]

Revision as of 15:40, 12 October 2014

Monomeric intronic human chl1 gene quadruplex DNA NMR, 17 structures

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