2fkd

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[[Image:2fkd.png|left|200px]]
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==Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor==
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<StructureSection load='2fkd' size='340' side='right' caption='[[2fkd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fkd]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_186 Enterobacteria phage 186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FKD FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29252 Enterobacteria phage 186])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fkd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fkd RCSB], [http://www.ebi.ac.uk/pdbsum/2fkd PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/2fkd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacteriophage lambda is a paradigm for understanding the role of cooperativity in gene regulation. Comparison of the regulatory regions of lambda and the unrelated temperate bacteriophage 186 provides insight into alternate ways to assemble functional genetic switches. The structure of the C-terminal domain of the 186 repressor, determined at 2.7 A resolution, reveals an unusual heptamer of dimers, consistent with presented genetic studies. In addition, the structure of a cooperativity mutant of the full-length 186 repressor, identified by genetic screens, was solved to 1.95 A resolution. These structures provide a molecular basis for understanding lysogenic regulation in 186. Whereas the overall fold of the 186 and lambda repressor monomers is remarkably similar, the way the two repressors cooperatively assemble is quite different and explains in part the differences in their regulatory activity.
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{{STRUCTURE_2fkd| PDB=2fkd | SCENE= }}
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The structural basis of cooperative regulation at an alternate genetic switch.,Pinkett HW, Shearwin KE, Stayrook S, Dodd IB, Burr T, Hochschild A, Egan JB, Lewis M Mol Cell. 2006 Mar 3;21(5):605-15. PMID:16507359<ref>PMID:16507359</ref>
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===Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16507359}}
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==See Also==
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*[[Bacteriophage repressor|Bacteriophage repressor]]
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==About this Structure==
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== References ==
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[[2fkd]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_186 Enterobacteria phage 186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKD OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016507359</ref><references group="xtra"/>
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[[Category: Enterobacteria phage 186]]
[[Category: Enterobacteria phage 186]]
[[Category: Lewis, M.]]
[[Category: Lewis, M.]]

Revision as of 02:10, 30 September 2014

Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor

2fkd, resolution 2.70Å

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