This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2gwl
From Proteopedia
m (Protected "2gwl" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2gwl.png|left|200px]] | ||
| - | |||
{{STRUCTURE_2gwl| PDB=2gwl | SCENE= }} | {{STRUCTURE_2gwl| PDB=2gwl | SCENE= }} | ||
| - | |||
===Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH=== | ===Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH=== | ||
| + | {{ABSTRACT_PUBMED_16905096}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/SPVB_SALCH SPVB_SALCH]] Mono-ADP-ribosylates eukaryotic muscle and non-muscle actin on 'Arg-177'. ADP-ribosylation prevents the polymerization of G-actin to F-actin, causing actin filament depolymerization, destruction of the cytoskeleton and cytotoxicity. Does not possess NAD(+)-glycohydrolase activity, unlike most mART enzymes (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 10: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016905096</ref><references group="xtra"/> | + | <ref group="xtra">PMID:016905096</ref><references group="xtra"/><references/> |
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | [[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | ||
[[Category: Margarit, S M.]] | [[Category: Margarit, S M.]] | ||
Revision as of 08:28, 30 October 2013
Contents |
Crystal structure of the Salmonella SpvB ATR Domain in complex with NADH
Template:ABSTRACT PUBMED 16905096
Function
[SPVB_SALCH] Mono-ADP-ribosylates eukaryotic muscle and non-muscle actin on 'Arg-177'. ADP-ribosylation prevents the polymerization of G-actin to F-actin, causing actin filament depolymerization, destruction of the cytoskeleton and cytotoxicity. Does not possess NAD(+)-glycohydrolase activity, unlike most mART enzymes (By similarity).
About this Structure
2gwl is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.
Reference
- Margarit SM, Davidson W, Frego L, Stebbins CE. A steric antagonism of actin polymerization by a salmonella virulence protein. Structure. 2006 Aug;14(8):1219-29. PMID:16905096 doi:10.1016/j.str.2006.05.022
