2idn

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[[Image:2idn.png|left|200px]]
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==NMR structure of a new modified Thrombin Binding Aptamer containing a 5'-5' inversion of polarity site==
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<StructureSection load='2idn' size='340' side='right' caption='[[2idn]], [[NMR_Ensembles_of_Models | 7 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2idn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IDN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2idn RCSB], [http://www.ebi.ac.uk/pdbsum/2idn PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of a new modified thrombin binding aptamer (TBA) containing a 5'-5' inversion of polarity site, namely d(3'GGT5'-5'TGGTGTGGTTGG3'), is reported. NMR and CD spectroscopy, as well as molecular dynamic and mechanic calculations, have been used to characterize the 3D structure. The modified oligonucleotide is characterized by a chair-like structure consisting of two G-tetrads connected by three edge-wise TT, TGT and TT loops. d(3'GGT5'-5'TGGTGTGGTTGG3') is characterized by an unusual folding, being three strands parallel to each other and only one strand oriented in opposite manner. This led to an anti-anti-anti-syn and syn-syn-syn-anti arrangement of the Gs in the two tetrads. The thermal stability of the modified oligonucleotide is 4 degrees C higher than the corresponding unmodified TBA. d(3'GGT5'-5'TGGTGTGGTTGG3') continues to display an anticoagulant activity, even if decreased with respect to the TBA.
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{{STRUCTURE_2idn| PDB=2idn | SCENE= }}
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A new modified thrombin binding aptamer containing a 5'-5' inversion of polarity site.,Martino L, Virno A, Randazzo A, Virgilio A, Esposito V, Giancola C, Bucci M, Cirino G, Mayol L Nucleic Acids Res. 2006;34(22):6653-62. Epub 2006 Dec 1. PMID:17145716<ref>PMID:17145716</ref>
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===NMR structure of a new modified Thrombin Binding Aptamer containing a 5'-5' inversion of polarity site===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17145716}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2idn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDN OCA].
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</StructureSection>
[[Category: Giancola, C.]]
[[Category: Giancola, C.]]
[[Category: Martino, L.]]
[[Category: Martino, L.]]

Revision as of 15:38, 12 October 2014

NMR structure of a new modified Thrombin Binding Aptamer containing a 5'-5' inversion of polarity site

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