2vh2

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[[Image:2vh2.png|left|200px]]
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==CRYSTAL STRUCTURE OF CELL DIVISON PROTEIN FTSQ FROM YERSINIA ENTERECOLITICA==
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<StructureSection load='2vh2' size='340' side='right' caption='[[2vh2]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VH2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vh2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vh2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vh2 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vh/2vh2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial cytokinesis requires the divisome, a complex of proteins that co-ordinates the invagination of the cytoplasmic membrane, inward growth of the peptidoglycan layer and the outer membrane. Assembly of the cell division proteins is tightly regulated and the order of appearance at the future division site is well organized. FtsQ is a highly conserved component of the divisome among bacteria that have a cell wall, where it plays a central role in the assembly of early and late cell division proteins. Here, we describe the crystal structure of the major, periplasmic domain of FtsQ from Escherichia coli and Yersinia enterocolitica. The crystal structure reveals two domains; the alpha-domain has a striking similarity to polypeptide transport-associated (POTRA) domains and the C-terminal beta-domain forms an extended beta-sheet overlaid by two, slightly curved alpha-helices. Mutagenesis experiments demonstrate that two functions of FtsQ, localization and recruitment, occur in two separate domains. Proteins that localize FtsQ need the second beta-strand of the POTRA domain and those that are recruited by FtsQ, like FtsL/FtsB, require the surface formed by the tip of the last alpha-helix and the two C-terminal beta-strands. Both domains act together to accomplish the role of FtsQ in linking upstream and downstream cell division proteins within the divisome.
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{{STRUCTURE_2vh2| PDB=2vh2 | SCENE= }}
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Structural and mutational analysis of the cell division protein FtsQ.,van den Ent F, Vinkenvleugel TM, Ind A, West P, Veprintsev D, Nanninga N, den Blaauwen T, Lowe J Mol Microbiol. 2008 Apr;68(1):110-23. Epub 2008 Feb 26. PMID:18312270<ref>PMID:18312270</ref>
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===CRYSTAL STRUCTURE OF CELL DIVISON PROTEIN FTSQ FROM YERSINIA ENTERECOLITICA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18312270}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2vh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VH2 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018312270</ref><references group="xtra"/>
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[[Category: Yersinia enterocolitica]]
[[Category: Yersinia enterocolitica]]
[[Category: Blaauwen, T Den.]]
[[Category: Blaauwen, T Den.]]

Revision as of 01:12, 1 October 2014

CRYSTAL STRUCTURE OF CELL DIVISON PROTEIN FTSQ FROM YERSINIA ENTERECOLITICA

2vh2, resolution 3.40Å

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