2rcz

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[[Image:2rcz.png|left|200px]]
 
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{{STRUCTURE_2rcz| PDB=2rcz | SCENE= }}
{{STRUCTURE_2rcz| PDB=2rcz | SCENE= }}
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===Structure of the second PDZ domain of ZO-1===
===Structure of the second PDZ domain of ZO-1===
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{{ABSTRACT_PUBMED_17928286}}
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{{ABSTRACT_PUBMED_17928286}}
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==Function==
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[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017928286</ref><references group="xtra"/>
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<ref group="xtra">PMID:017928286</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lavie, A.]]
[[Category: Lavie, A.]]

Revision as of 07:31, 30 June 2013

Template:STRUCTURE 2rcz

Contents

Structure of the second PDZ domain of ZO-1

Template:ABSTRACT PUBMED 17928286

Function

[ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.[1]

About this Structure

2rcz is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Fanning AS, Lye MF, Anderson JM, Lavie A. Domain swapping within PDZ2 is responsible for dimerization of ZO proteins. J Biol Chem. 2007 Dec 28;282(52):37710-6. Epub 2007 Oct 9. PMID:17928286 doi:10.1074/jbc.M707255200
  1. ↑ Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187 doi:10.1038/emboj.2010.353

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OCA

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