1xb9
From Proteopedia
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| - | [[Image:1xb9.gif|left|200px]] | + | [[Image:1xb9.gif|left|200px]] |
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| - | '''The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus''' | + | {{Structure |
| + | |PDB= 1xb9 |SIZE=350|CAPTION= <scene name='initialview01'>1xb9</scene>, resolution 1.90Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XB9 is a [ | + | 1XB9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB9 OCA]. |
==Reference== | ==Reference== | ||
| - | The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus., Namboodiri VM, Akey IV, Schmidt-Zachmann MS, Head JF, Akey CW, Structure. 2004 Dec;12(12):2149-60. PMID:[http:// | + | The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus., Namboodiri VM, Akey IV, Schmidt-Zachmann MS, Head JF, Akey CW, Structure. 2004 Dec;12(12):2149-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576029 15576029] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
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[[Category: x-ray crystallography]] | [[Category: x-ray crystallography]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:07:29 2008'' |
Revision as of 13:07, 20 March 2008
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The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus
Overview
Xenopus NO38 is an abundant nucleolar chaperone and a member of the nucleoplasmin (Np) family. Here, we report high-resolution crystal structures of the N-terminal domain of NO38, as a pentamer and a decamer. As expected, NO38 shares the Np family fold. In addition, NO38- and Np-core pentamers each use highly conserved residues and numerous waters to form their respective decamers. Further studies show that NO38 and Np each bind equal amounts of the four core histones. However, NO38 prefers the (H3-H4)(2) tetramer, while Np probably prefers H2A-H2B dimers. We also show that NO38 and Np will each bind noncognate histones when the preferred partner is absent. We suggest that these chaperones must form decamers in order to bind histones and differentiate between histone tetramers and dimers. When taken together, these data imply that NO38 may function as a histone chaperone in the nucleolus.
About this Structure
1XB9 is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.
Reference
The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus., Namboodiri VM, Akey IV, Schmidt-Zachmann MS, Head JF, Akey CW, Structure. 2004 Dec;12(12):2149-60. PMID:15576029
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