1xdx
From Proteopedia
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| - | [[Image:1xdx.gif|left|200px]] | + | [[Image:1xdx.gif|left|200px]] |
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| - | '''Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1''' | + | {{Structure |
| + | |PDB= 1xdx |SIZE=350|CAPTION= <scene name='initialview01'>1xdx</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= AF039437 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 Chlamydomonas reinhardtii]) | ||
| + | }} | ||
| + | |||
| + | '''Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XDX is a [ | + | 1XDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions., Wu H, Maciejewski MW, Takebe S, King SM, Structure. 2005 Feb;13(2):213-23. PMID:[http:// | + | Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions., Wu H, Maciejewski MW, Takebe S, King SM, Structure. 2005 Feb;13(2):213-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15698565 15698565] |
[[Category: Chlamydomonas reinhardtii]] | [[Category: Chlamydomonas reinhardtii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tctex1 dimer]] | [[Category: tctex1 dimer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:08:29 2008'' |
Revision as of 13:08, 20 March 2008
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| Gene: | AF039437 (Chlamydomonas reinhardtii) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1
Overview
Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.
About this Structure
1XDX is a Single protein structure of sequence from Chlamydomonas reinhardtii. Full crystallographic information is available from OCA.
Reference
Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions., Wu H, Maciejewski MW, Takebe S, King SM, Structure. 2005 Feb;13(2):213-23. PMID:15698565
Page seeded by OCA on Thu Mar 20 15:08:29 2008
