1xfh
From Proteopedia
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| - | [[Image:1xfh.gif|left|200px]] | + | [[Image:1xfh.gif|left|200px]] |
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| - | '''Structure of glutamate transporter homolog from Pyrococcus horikoshii''' | + | {{Structure |
| + | |PDB= 1xfh |SIZE=350|CAPTION= <scene name='initialview01'>1xfh</scene>, resolution 3.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= GltPh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii OT3]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of glutamate transporter homolog from Pyrococcus horikoshii''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XFH is a [ | + | 1XFH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii_ot3 Pyrococcus horikoshii ot3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFH OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a glutamate transporter homologue from Pyrococcus horikoshii., Yernool D, Boudker O, Jin Y, Gouaux E, Nature. 2004 Oct 14;431(7010):811-8. PMID:[http:// | + | Structure of a glutamate transporter homologue from Pyrococcus horikoshii., Yernool D, Boudker O, Jin Y, Gouaux E, Nature. 2004 Oct 14;431(7010):811-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15483603 15483603] |
[[Category: Pyrococcus horikoshii ot3]] | [[Category: Pyrococcus horikoshii ot3]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: trimeric helical transmembrane protein]] | [[Category: trimeric helical transmembrane protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:09:09 2008'' |
Revision as of 13:09, 20 March 2008
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| , resolution 3.50Å | |||||||
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| Gene: | GltPh (Pyrococcus horikoshii OT3) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of glutamate transporter homolog from Pyrococcus horikoshii
Overview
Glutamate transporters are integral membrane proteins that catalyse the concentrative uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion gradients. In the central nervous system glutamate transporters are essential for normal development and function, and are implicated in stroke, epilepsy and neurodegenerative diseases. Here we present the crystal structure of a eukaryotic glutamate transporter homologue from Pyrococcus horikoshii. The transporter is a bowl-shaped trimer with a solvent-filled extracellular basin extending halfway across the membrane bilayer. At the bottom of the basin are three independent binding sites, each cradled by two helical hairpins, reaching from opposite sides of the membrane. We propose that transport of glutamate is achieved by movements of the hairpins that allow alternating access to either side of the membrane.
About this Structure
1XFH is a Single protein structure of sequence from Pyrococcus horikoshii ot3. Full crystallographic information is available from OCA.
Reference
Structure of a glutamate transporter homologue from Pyrococcus horikoshii., Yernool D, Boudker O, Jin Y, Gouaux E, Nature. 2004 Oct 14;431(7010):811-8. PMID:15483603
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