2qp2

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[[Image:2qp2.png|left|200px]]
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==Structure of a MACPF/perforin-like protein==
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<StructureSection load='2qp2' size='340' side='right' caption='[[2qp2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qp2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Photorhabdus_luminescens_subsp._laumondii Photorhabdus luminescens subsp. laumondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QP2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Photorhabdus luminescens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=141679 Photorhabdus luminescens subsp. laumondii])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qp2 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qp/2qp2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell migration. In vertebrates, the ninth component of complement and perforin form oligomeric pores that lyse bacteria and kill virus-infected cells, respectively. However, the mechanism of MACPF function is unknown. We determined the crystal structure of a bacterial MACPF protein, Plu-MACPF from Photorhabdus luminescens, to 2.0 angstrom resolution. The MACPF domain reveals structural similarity with poreforming cholesterol-dependent cytolysins (CDCs) from Gram-positive bacteria. This suggests that lytic MACPF proteins may use a CDC-like mechanism to form pores and disrupt cell membranes. Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection.
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{{STRUCTURE_2qp2| PDB=2qp2 | SCENE= }}
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A common fold mediates vertebrate defense and bacterial attack.,Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC Science. 2007 Sep 14;317(5844):1548-51. Epub 2007 Aug 23. PMID:17717151<ref>PMID:17717151</ref>
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===Structure of a MACPF/perforin-like protein===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17717151}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2qp2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Photorhabdus_luminescens_subsp._laumondii Photorhabdus luminescens subsp. laumondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QP2 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017717151</ref><ref group="xtra">PMID:019119857</ref><references group="xtra"/>
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[[Category: Photorhabdus luminescens subsp. laumondii]]
[[Category: Photorhabdus luminescens subsp. laumondii]]
[[Category: Baran, K.]]
[[Category: Baran, K.]]

Revision as of 19:34, 30 September 2014

Structure of a MACPF/perforin-like protein

2qp2, resolution 2.00Å

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