3al6
From Proteopedia
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{{STRUCTURE_3al6| PDB=3al6 | SCENE= }} | {{STRUCTURE_3al6| PDB=3al6 | SCENE= }} | ||
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===Crystal structure of Human TYW5=== | ===Crystal structure of Human TYW5=== | ||
| + | {{ABSTRACT_PUBMED_20972222}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/TYW5_HUMAN TYW5_HUMAN]] tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.<ref>PMID:20739293</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:020972222</ref><references group="xtra"/> | + | <ref group="xtra">PMID:020972222</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Araiso, Y.]] | [[Category: Araiso, Y.]] | ||
Revision as of 18:58, 7 August 2013
Contents |
Crystal structure of Human TYW5
Template:ABSTRACT PUBMED 20972222
Function
[TYW5_HUMAN] tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.[1]
About this Structure
3al6 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O. Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. Nucleic Acids Res. 2010 Oct 23. PMID:20972222 doi:10.1093/nar/gkq919
- ↑ Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T. Expanding role of the jumonji C domain as an RNA hydroxylase. J Biol Chem. 2010 Nov 5;285(45):34503-7. doi: 10.1074/jbc.M110.156398. Epub 2010 , Aug 25. PMID:20739293 doi:10.1074/jbc.M110.156398
