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2vvt

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[[Image:2vvt.png|left|200px]]
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==GLUTAMATE RACEMASE (MURI) FROM E. FAECALIS IN COMPLEX WITH A 9-BENZYL PURINE INHIBITOR==
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<StructureSection load='2vvt' size='340' side='right' caption='[[2vvt]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vvt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VVT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=I24:2-BUTOXY-9-(2,6-DIFLUOROBENZYL)-N-(2-MORPHOLIN-4-YLETHYL)-9H-PURIN-6-AMINE'>I24</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jfp|2jfp]], [[2jfo|2jfo]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vvt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vvt RCSB], [http://www.ebi.ac.uk/pdbsum/2vvt PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vvt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
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{{STRUCTURE_2vvt| PDB=2vvt | SCENE= }}
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Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.,Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. Epub 2008 Jun 24. PMID:18614367<ref>PMID:18614367</ref>
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===GLUTAMATE RACEMASE (MURI) FROM E. FAECALIS IN COMPLEX WITH A 9-BENZYL PURINE INHIBITOR===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18614367}}
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==See Also==
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*[[Glutamate racemase|Glutamate racemase]]
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==About this Structure==
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== References ==
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[[2vvt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VVT OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018614367</ref><references group="xtra"/>
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[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
[[Category: Glutamate racemase]]
[[Category: Glutamate racemase]]

Revision as of 01:55, 1 October 2014

GLUTAMATE RACEMASE (MURI) FROM E. FAECALIS IN COMPLEX WITH A 9-BENZYL PURINE INHIBITOR

2vvt, resolution 1.65Å

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