1xnf
From Proteopedia
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| - | [[Image:1xnf.jpg|left|200px]] | + | [[Image:1xnf.jpg|left|200px]] |
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| - | '''Crystal structure of E.coli TPR-protein NlpI''' | + | {{Structure |
| + | |PDB= 1xnf |SIZE=350|CAPTION= <scene name='initialview01'>1xnf</scene>, resolution 1.98Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= nlpi ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of E.coli TPR-protein NlpI''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XNF is a [ | + | 1XNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNF OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold., Wilson CG, Kajander T, Regan L, FEBS J. 2005 Jan;272(1):166-79. PMID:[http:// | + | The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold., Wilson CG, Kajander T, Regan L, FEBS J. 2005 Jan;272(1):166-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15634341 15634341] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: lipoprotein]] | [[Category: lipoprotein]] | ||
[[Category: nlpi]] | [[Category: nlpi]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: tetratricopeptide]] | [[Category: tetratricopeptide]] | ||
[[Category: tpr]] | [[Category: tpr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:09 2008'' |
Revision as of 13:12, 20 March 2008
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| , resolution 1.98Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | nlpi (Escherichia coli) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of E.coli TPR-protein NlpI
Overview
There are several different families of repeat proteins. In each, a distinct structural motif is repeated in tandem to generate an elongated structure. The nonglobular, extended structures that result are particularly well suited to present a large surface area and to function as interaction domains. Many repeat proteins have been demonstrated experimentally to fold and function as independent domains. In tetratricopeptide (TPR) repeats, the repeat unit is a helix-turn-helix motif. The majority of TPR motifs occur as three to over 12 tandem repeats in different proteins. The majority of TPR structures in the Protein Data Bank are of isolated domains. Here we present the high-resolution structure of NlpI, the first structure of a complete TPR-containing protein. We show that in this instance the TPR motifs do not fold and function as an independent domain, but are fully integrated into the three-dimensional structure of a globular protein. The NlpI structure is also the first TPR structure from a prokaryote. It is of particular interest because it is a membrane-associated protein, and mutations in it alter septation and virulence.
About this Structure
1XNF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold., Wilson CG, Kajander T, Regan L, FEBS J. 2005 Jan;272(1):166-79. PMID:15634341
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