3cji

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[[Image:3cji.png|left|200px]]
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==Structure of Seneca Valley Virus-001==
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<StructureSection load='3cji' size='340' side='right' caption='[[3cji]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3cji]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Seneca_valley_virus Seneca valley virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cji RCSB], [http://www.ebi.ac.uk/pdbsum/3cji PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cji_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of Seneca Valley Virus-001 (SVV-001), the representative member of a new genus, Senecavirus, is reported at 2.3A resolution. SVV-001 is the first naturally occurring nonpathogenic picornavirus shown to mediate selective cytotoxicity towards tumor cells with neuroendocrine cancer features. The nonsegmented (+) ssRNA genome of SVV-001 shares closest sequence similarity with the genomes of the members of Cardiovirus. The overall tertiary structure of VP1-VP4 subunits is conserved with the exception of loops, especially those of VP1 that show large deviations relative to the members of the cardioviruses. The surface loops of VP1 and VP2 are predicted to mediate cell tropism of SVV-001. In addition, the organization of the packaged nucleic acid density indicates that certain regions of VP2 and VP4 interact closely with the packaged nucleic acid.
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{{STRUCTURE_3cji| PDB=3cji | SCENE= }}
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Structure of Seneca Valley Virus-001: an oncolytic picornavirus representing a new genus.,Venkataraman S, Reddy SP, Loo J, Idamakanti N, Hallenbeck PL, Reddy VS Structure. 2008 Oct 8;16(10):1555-61. PMID:18940610<ref>PMID:18940610</ref>
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===Structure of Seneca Valley Virus-001===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18940610}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3cji]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Seneca_valley_virus Seneca valley virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJI OCA].
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</StructureSection>
[[Category: Seneca valley virus]]
[[Category: Seneca valley virus]]
[[Category: Reddy, V S.]]
[[Category: Reddy, V S.]]

Revision as of 21:18, 2 October 2014

Structure of Seneca Valley Virus-001

3cji, resolution 2.30Å

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OCA

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