2qrz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2qrz" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2qrz.png|left|200px]]
 
- 
{{STRUCTURE_2qrz| PDB=2qrz | SCENE= }}
{{STRUCTURE_2qrz| PDB=2qrz | SCENE= }}
- 
===Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required===
===Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required===
 +
{{ABSTRACT_PUBMED_18348980}}
-
{{ABSTRACT_PUBMED_18348980}}
+
==Function==
 +
[[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
==About this Structure==
==About this Structure==
Line 11: Line 10:
==Reference==
==Reference==
-
<ref group="xtra">PMID:018348980</ref><references group="xtra"/>
+
<ref group="xtra">PMID:018348980</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Calero, G.]]
[[Category: Calero, G.]]

Revision as of 07:43, 30 June 2013

Template:STRUCTURE 2qrz

Contents

Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required

Template:ABSTRACT PUBMED 18348980

Function

[CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.[1] [2] [3]

About this Structure

2qrz is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Phillips MJ, Calero G, Chan B, Ramachandran S, Cerione RA. Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42. J Biol Chem. 2008 May 16;283(20):14153-64. Epub 2008 Mar 18. PMID:18348980 doi:10.1074/jbc.M706271200
  1. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
  2. ↑ Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S. Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. J Cell Biol. 2005 Jan 17;168(2):221-32. Epub 2005 Jan 10. PMID:15642749 doi:10.1083/jcb.200408085
  3. ↑ Modzelewska K, Newman LP, Desai R, Keely PJ. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35. Epub 2006 Oct 12. PMID:17038317 doi:10.1074/jbc.M604342200

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qrz"
Personal tools