1xud
From Proteopedia
(Difference between revisions)
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| - | [[Image:1xud.jpg|left|200px]] | + | [[Image:1xud.jpg|left|200px]] |
| - | + | ||
| - | '''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor''' | + | {{Structure |
| + | |PDB= 1xud |SIZE=350|CAPTION= <scene name='initialview01'>1xud</scene>, resolution 1.800Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=PB4:N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE'>PB4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XUD is a [ | + | 1XUD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA]. |
==Reference== | ==Reference== | ||
| - | Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:[http:// | + | Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15734640 15734640] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: non-zinc binding inhibitor]] | [[Category: non-zinc binding inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:14:38 2008'' |
Revision as of 13:14, 20 March 2008
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| , resolution 1.800Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor
Overview
The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.
About this Structure
1XUD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640
Page seeded by OCA on Thu Mar 20 15:14:38 2008
