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1xud

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[[Image:1xud.jpg|left|200px]]<br /><applet load="1xud" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1xud.jpg|left|200px]]
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caption="1xud, resolution 1.800&Aring;" />
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'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''<br />
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{{Structure
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|PDB= 1xud |SIZE=350|CAPTION= <scene name='initialview01'>1xud</scene>, resolution 1.800&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=PB4:N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE'>PB4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1XUD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=PB4:'>PB4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA].
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1XUD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA].
==Reference==
==Reference==
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Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15734640 15734640]
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Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15734640 15734640]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: non-zinc binding inhibitor]]
[[Category: non-zinc binding inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:58:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:14:38 2008''

Revision as of 13:14, 20 March 2008

Image:1xud.jpg


PDB ID 1xud

Drag the structure with the mouse to rotate
, resolution 1.800Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor


Overview

The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.

About this Structure

1XUD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640

Page seeded by OCA on Thu Mar 20 15:14:38 2008

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OCA

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