2w8m
From Proteopedia
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| - | [[ | + | ==STRUCTURE OF D212, A NUCLEASE FROM A FUSSELOVIRUS.== |
| + | <StructureSection load='2w8m' size='340' side='right' caption='[[2w8m]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2w8m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_virus_ragged_hills Sulfolobus virus ragged hills]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W8M FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w8m RCSB], [http://www.ebi.ac.uk/pdbsum/2w8m PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Structural studies have made significant contributions to our understanding of Sulfolobus spindle-shaped viruses (Fuselloviridae), an important model system for archaeal viruses. Continuing these efforts, we report the structure of D212 from Sulfolobus spindle-shaped virus Ragged Hills. The overall fold and conservation of active site residues place D212 in the PD-(D/E)XK nuclease superfamily. The greatest structural similarity is found to the archaeal Holliday junction cleavage enzymes, strongly suggesting a role in DNA replication, repair, or recombination. Other roles associated with nuclease activity are also considered. | ||
| - | + | The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily.,Menon SK, Eilers BJ, Young MJ, Lawrence CM J Virol. 2010 Jun;84(12):5890-7. Epub 2010 Apr 7. PMID:20375162<ref>PMID:20375162</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Sulfolobus virus ragged hills]] | [[Category: Sulfolobus virus ragged hills]] | ||
[[Category: Lawrence, C M.]] | [[Category: Lawrence, C M.]] | ||
Revision as of 11:34, 20 October 2014
STRUCTURE OF D212, A NUCLEASE FROM A FUSSELOVIRUS.
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