1y39
From Proteopedia
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| - | [[Image:1y39.gif|left|200px]] | + | [[Image:1y39.gif|left|200px]] |
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| - | '''Co-evolution of protein and RNA structures within a highly conserved ribosomal domain''' | + | {{Structure |
| + | |PDB= 1y39 |SIZE=350|CAPTION= <scene name='initialview01'>1y39</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=3CO:COBALT+(III)+ION'>3CO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Co-evolution of protein and RNA structures within a highly conserved ribosomal domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Y39 is a [ | + | 1Y39 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y39 OCA]. |
==Reference== | ==Reference== | ||
| - | Coevolution of protein and RNA structures within a highly conserved ribosomal domain., Dunstan MS, Guhathakurta D, Draper DE, Conn GL, Chem Biol. 2005 Feb;12(2):201-6. PMID:[http:// | + | Coevolution of protein and RNA structures within a highly conserved ribosomal domain., Dunstan MS, Guhathakurta D, Draper DE, Conn GL, Chem Biol. 2005 Feb;12(2):201-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15734647 15734647] |
[[Category: Geobacillus stearothermophilus]] | [[Category: Geobacillus stearothermophilus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: x-ray crystal structure]] | [[Category: x-ray crystal structure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:17:56 2008'' |
Revision as of 13:17, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Ligands: | , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Co-evolution of protein and RNA structures within a highly conserved ribosomal domain
Overview
The X-ray crystal structure of a ribosomal L11-rRNA complex with chloroplast-like mutations in both protein and rRNA is presented. The global structure is almost identical to that of the wild-type (bacterial) complex, with only a small movement of the protein alpha helix away from the surface of the RNA required to accommodate the altered protein residue. In contrast, the specific hydrogen bonding pattern of the mutated residues is substantially different, and now includes a direct interaction between the protein side chain and an RNA base edge and a water-mediated contact. Comparison of the two structures allows the observations of sequence variation and relative affinities of wild-type and mutant complexes to be clearly rationalized, but reinforces the concept that there is no single simple code for protein-RNA recognition.
About this Structure
1Y39 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
Coevolution of protein and RNA structures within a highly conserved ribosomal domain., Dunstan MS, Guhathakurta D, Draper DE, Conn GL, Chem Biol. 2005 Feb;12(2):201-6. PMID:15734647
Page seeded by OCA on Thu Mar 20 15:17:56 2008
