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333d
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| - | [[ | + | ==THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES== |
| + | <StructureSection load='333d' size='340' side='right' caption='[[333d]], [[Resolution|resolution]] 2.52Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[333d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=333D FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=I:INOSINIC+ACID'>I</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=333d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=333d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=333d RCSB], [http://www.ebi.ac.uk/pdbsum/333d PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The X-ray crystallographic structure of the RNA duplex [r(CGCAIGCG)]2 has been refined to 2.5 A. It shows a symmetric internal loop of two non-Watson-Crick base pairs which form in the middle of the duplex. The tandem A-I/I-A pairs are related by a crystallographic two-fold axis. Both A(anti)-I(anti) mismatches are in a head-to-head conformation forming hydrogen bonds using the Watson-Crick positions. The octamer duplexes stack above one another in the cell forming a pseudo-infinite helix throughout the crystal. A hydrated calcium ion bridges between the 3'-terminal of one molecule and the backbone of another. The tandem A-I mismatches are incorporated with only minor distortion to the backbone. This is in contrast to the large helical perturbations often produced by sheared G-A pairs in RNA oligonucleotides. | ||
| - | + | The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches.,Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:9321667<ref>PMID:9321667</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
| - | [[Category: Baeyens, K J | + | [[Category: Baeyens, K J]] |
| - | [[Category: Carter, R J | + | [[Category: Carter, R J]] |
| - | [[Category: Holbrook, S R | + | [[Category: Holbrook, S R]] |
| - | [[Category: SantaLucia, J | + | [[Category: SantaLucia, J]] |
| - | [[Category: Turner, D H | + | [[Category: Turner, D H]] |
[[Category: A-rna]] | [[Category: A-rna]] | ||
[[Category: Double helix]] | [[Category: Double helix]] | ||
Revision as of 10:22, 20 January 2015
THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES
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Categories: Baeyens, K J | Carter, R J | Holbrook, S R | SantaLucia, J | Turner, D H | A-rna | Double helix | Internal loop | Mismatched | Rna
