3a5y

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m (Protected "3a5y" [edit=sysop:move=sysop])
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[[Image:3a5y.png|left|200px]]
 
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{{STRUCTURE_3a5y| PDB=3a5y | SCENE= }}
{{STRUCTURE_3a5y| PDB=3a5y | SCENE= }}
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===Crystal structure of GenX from Escherichia coli in complex with lysyladenylate analog===
===Crystal structure of GenX from Escherichia coli in complex with lysyladenylate analog===
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{{ABSTRACT_PUBMED_20729861}}
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{{ABSTRACT_PUBMED_20729861}}
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==Function==
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[[http://www.uniprot.org/uniprot/C3SGA2_ECOLX C3SGA2_ECOLX]] With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34' (By similarity).[HAMAP-Rule:MF_00174]
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020729861</ref><references group="xtra"/>
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<ref group="xtra">PMID:020729861</ref><references group="xtra"/><references/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Lysine--tRNA ligase]]
[[Category: Lysine--tRNA ligase]]

Revision as of 05:26, 23 October 2013

Template:STRUCTURE 3a5y

Contents

Crystal structure of GenX from Escherichia coli in complex with lysyladenylate analog

Template:ABSTRACT PUBMED 20729861

Function

[C3SGA2_ECOLX] With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34' (By similarity).[HAMAP-Rule:MF_00174]

About this Structure

3a5y is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Yanagisawa T, Sumida T, Ishii R, Takemoto C, Yokoyama S. A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat Struct Mol Biol. 2010 Sep;17(9):1136-43. Epub 2010 Aug 22. PMID:20729861 doi:10.1038/nsmb.1889

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OCA

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