2wyn

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[[Image:2wyn.png|left|200px]]
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==STRUCTURE OF FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH A CASUARINE-6-O-A-D-GLUCOSIDE ANALOGUE==
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<StructureSection load='2wyn' size='340' side='right' caption='[[2wyn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wyn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WYN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=LG9:(1R,2R,3R,6R,7R,7AR)-3,7-BIS(HYDROXYMETHYL)HEXAHYDRO-1H-PYRROLIZINE-1,2,6-TRIOL'>LG9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jjb|2jjb]], [[2jg0|2jg0]], [[2jf4|2jf4]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha,alpha-trehalase Alpha,alpha-trehalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.28 3.2.1.28] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wyn RCSB], [http://www.ebi.ac.uk/pdbsum/2wyn PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wy/2wyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.
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{{STRUCTURE_2wyn| PDB=2wyn | SCENE= }}
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Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.,Cardona F, Goti A, Parmeggiani C, Parenti P, Forcella M, Fusi P, Cipolla L, Roberts SM, Davies GJ, Gloster TM Chem Commun (Camb). 2010 Apr 21;46(15):2629-31. PMID:20461849<ref>PMID:20461849</ref>
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===STRUCTURE OF FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH A CASUARINE-6-O-A-D-GLUCOSIDE ANALOGUE===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20461849}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2wyn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYN OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020461849</ref><references group="xtra"/>
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[[Category: Alpha,alpha-trehalase]]
[[Category: Alpha,alpha-trehalase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]

Revision as of 13:09, 22 October 2014

STRUCTURE OF FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH A CASUARINE-6-O-A-D-GLUCOSIDE ANALOGUE

2wyn, resolution 2.10Å

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